A failed mission to protect a scientist who has stolen a copy of the smallpox virus left Jon Man (Jay Chou) severely injured and the scientist kidnapped by his traitorous colleague Sean (Andy On). The bullet is lodged in Jon's brain will paralyses him within two week and he decides to spend his final days with his mother (Elaine Jin).
What he didn't expect was that his mother revealed to him that he has a long lost brother Man Yang (Nicolas Tse) whom she left behind with his gambling addict dad Man Tin (Liu Kai Chi). To fulfill his mother last wishes, Jon decides to track Man Yang down in Malaysia.
En route to Kuala Lumpur (Capital of Malaysia), Jon befriends medical specialist Rachel (Lin Peng) and came across criminal organization attempting to kidnap her. During the process to foil this kidnap attempt, he discovers that Man Yang is a wanted felon working as a mercenary for Sean, who needs the help of a medical specialist to mutate the small pox virus and holds the world ransom.
After Man Yang failed to kidnap Rachel but escaped with the virus, the criminal organization attempts to control him by kidnapping his daughter. The righteous Jon has to decide whether to stop Man Yang from breaking more laws or assist his wayward brother in rescuing his niece and stopping Sean's diabolical plans?
